Agency for Healthcare Research and Quality
- Using Innovative Digital Healthcare Solutions to Improve Quality at the Point of Care (R21/R33 - Clinical Trial Optional) multiple due dates until 8/1/2026
The objective of this NOFO is to improve the quality of healthcare services delivery at the point of care through integration of digital healthcare solutions. This NOFO aims to support phased exploratory and developmental research projects that test promising digital healthcare interventions used at the point of care and intended to improve the quality of healthcare services delivery. - Examining the Impact of Artificial Intelligence (AI) on Healthcare Safety (R18) multiple due dates until 5/26/2027
The purpose of this NOFO is to invite grant applications that support healthcare safety by determining (1) whether and how certain breakthrough uses of Artificial Intelligence (AI) systems can affect patient safety; and (2) how AI systems can be safely implemented and used.
ARPA-H
- Performance and Reliability Evaluation for Continuous modIfications and uSEability of AI (PRECISE-AI) due 1/15/2025
Aims to create a suite of self-correction techniques that make it possible to automatically maintain peak model performance of predictive AI components across diverse clinical settings. PRECISE-AI will advance novel approaches to optimally support clinician decision-making and scalably manage the performance of AI Decision Support Tools (AI-DSTs) after their commercial deployment.
Department of Defense
- FY25 Minerva Research Initiative University Research Program due 2/28/2025
Topic 5, Social Impact of Technological Change, seeks to explore the impact(s) of emerging technologies on social structures and concomitant relationships. Particularly, it is comparatively concerned with how the impact of technological change varies across different societies and across micro-, meso-, and macro-scales. - DARPA Biological Technologies Office (BTO) Broad Agency Announcement rolling until 9/10/2025
Topics of interest related to AI/ML include biological data generation, assessment, and incorporation into the biological foundation models, developing ML and AI-enabled technologies to improve the accuracy, precision and efficiency of warfighter decision-making, and the development of visual testbeds, digital twins, and/or synthetic data. - DARPA Information Innovation Office (I2O) Broad Agency Announcement rolling until 10/29/25
The Information Innovation Office (I2O) creates groundbreaking science and develops
transformational capabilities in the informational and computational spheres to surprise
adversaries and maintain enduring advantages for national security. I2O programs address
elements of four key thrust areas: Proficient artificial intelligence (AI); Resilient, adaptable, and secure systems; Advantage in cyber operations; and Confidence in the information domain. - Geospatial Intelligence Processing and Exploitation (GeoPEX) Broad Agency Announcement rolling until 9/30/2026
The Air Force Research Laboratory seeks white papers for research, development, integration, test and evaluation of technologies/techniques to provide geospatial intelligence. - DEVCOM Army Research Laboratory Broad Agency Announcement for Foundational Research rolling until 11/20/2027
Current research topics include AI Model Optimization for Real-Time, Scalable Data Analytics, Artificial Intelligence and Machine Learning with Extremely Sparse Data, Artificial Intelligence and Machine Learning-Enabling Technologies for Expeditionary Maneuver and Air/Ground Reconnaissance, Artificial Intelligence and Machine Learning: Managing Massive Data Sets. - DEVCOM Analysis Center Broad Agency Announcement For Applied Research rolling until 1/4/2028
Current research topics include Human-Systems Integration Analysis – Artificial Intelligence/Machine Learning for Army System Development and Assessment, Methodologies and Techniques to Analyze Assistive Automation (AA) & Artificial Intelligence (AI) enabled systems, Network Vulnerability and Effects Assessment Methodology (N-VEAM). - Artificial Intelligence Integration Center (AI2C) Broad Agency Announcement rolling until 5/31/2029
The Army Artificial Intelligence Integration Center (AI2C) is seeking artificial intelligence research and development whitepapers and proposals in support of new technologies and translational research-based approaches that support the identification, alignment, and exploitation of basic, applied, and advanced research and technology.
Department of Energy
- FY 2025 Continuation of Solicitation for the Office of Science Financial Assistance Program due per solicitation
The Office of Science indicates interest in AI/ML proposals across all of its programs. Some programs use the open call to solicit research proposals, while other programs areas issue targeted funding solicitations for research.
National Endowment for the Humanities
- Collaborative Research due 11/20/2024
The Collaborative Research funding opportunity advances humanistic knowledge by supporting teams of scholars working on a joint endeavor. Eligible projects include planning of an international AI research project or scholarly convening about AI. Part of NEH's Humanities Perspectives on Artificial Intelligence initiative. - Institutes for Advanced Topics in the Digital Humanities due 2/13/2025
This NEH grant program supports national or regional training programs for scholars, humanities professionals, and advanced graduate students to broaden and extend their knowledge of digital humanities. Eligible projects include professional development programs on the latest research related to humanistic AI. Part of NEH's Humanities Perspectives on Artificial Intelligence initiative. - Dangers and Opportunities of Technology: Perspectives from the Humanities due 9/4/2025
This NEH funding opportunity supports individuals and teams of scholars engaged in research that examines technology and its relationship to society through the lens of the humanities, with a focus on the dangers and/or opportunities presented by technology. Part of NEH's Humanities Perspectives on Artificial Intelligence initiative.
National Institutes of Health
- NOSI: Validation of Digital Health and Artificial Intelligence/Machine Learning Tools for Improved Assessment in Biomedical and Behavioral Research multiple due dates until 7/6/2025
The purpose of this Notice of Special Interest (NOSI) is to encourage grant applications to support the evaluation of the utility and validity of digital health and artificial intelligence/machine learning (AI/ML) tools and technologies in biomedical and behavioral research. - NOSI: Explainable Artificial Intelligence for Decoding and Modulating Neural Circuit Activity Linked to Behavior multiple due dates until 2/6/26
The eXplainable Artificial Intelligence (XAI) framework aims to provide strong predictive value along with a mechanistic understanding of AI solutions by combining machine learning techniques with effective explanatory techniques. This Notice of Special Interest (NOSI) solicits applications in the area of XAI applied to neuroscientific questions of encoding, decoding, and modulation of neural circuits linked to behavior. - NOSI: Advancing Data Science Research in HIV: Responding to a Dynamic, Complex, and Evolving HIV Epidemic with Artificial Intelligence/Machine Learning multiple due dates until 1/8/2027
This NOSI seeks to advance data science research in HIV by encouraging the generation of cutting-edge synthetic datasets, artificial intelligence, and machine learning approaches to expand our capacity to address the dynamic, complex, and evolving HIV epidemic. - NOSI: Application of Artificial Intelligence in Treatment Development for Substance Use Disorders multiple due dates until 9/7/2028
The purpose of this Notice of Special Interest (NOSI) is to elicit projects that would leverage the power of generative AI/ML and predictive models to accelerate medication discovery and development for treatment of SUDs while reducing the risk of failure.
National Science Foundation
- Dear Colleague Letter: Planning Grants to Create Artificial Intelligence (AI)-Ready Test Beds due 11/13/2024
Encourages Planning Grants that expand existing test beds and infrastructure to make them AI-ready and appropriate for use in evaluating the impact and effect of AI tools and systems on users. - Science of Learning and Augmented Intelligence due 2/12/2025
Supports research to develop fundamental knowledge about principles, processes and mechanisms of learning and about augmented intelligence — how human cognitive function can be augmented through interactions with others and technology. - Mathematical Foundations of Digital Twins (MATH-DT) due 3/17/2025
Supports foundational mathematical and statistical research on digital twins in applied science to harness science, technology and innovation to address society’s most pressing challenges. - Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation (FDT-BioTech) due 5/5/2025
Supports interdisciplinary research projects that explore the mathematical and engineering foundations behind the development and use of digital twins in biomedical and healthcare applications. - ACED: Accelerating Computing-Enabled Scientific Discovery (ACED) due 5/5/2025
Supports interdisciplinary collaborative research to explore new computational technologies and accelerate scientific discovery. - Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) due 10/3/2025
Supports the development of transformative advances in computer and information science, engineering, mathematics, statistics, behavioral and cognitive research to address pressing questions in the biomedical and public health communities. - Dear Colleague Letter: Advancing Research at the intersection of Biology and Artificial Intelligence (AI)/Machine Learning (ML) due per solicitation
BIO encourages the submission of proposals that advance biological research using Artificial Intelligence/Machine Learning (AI/ML) or AI/ML methods using biological data and systems. - Dear Colleague Letter: Advancing Research in the Geosciences Using Artificial Intelligence (AI) and Machine Learning (ML) due per solicitation
GEO encourages the submission of proposals that advance our understanding of geosciences using Artificial Intelligence (AI) and Machine Learning (ML) methods. - Foundational Research in Robotics (FRR) due per solicitation
Supports research on robotic systems that exhibit significant levels of both computational capability and physical complexity. For the purposes of this program, a robot is defined as intelligence embodied in an engineered construct, with the ability to process information, sense, plan, and move within or substantially alter its working environment. - Cyber-Physical Systems (CPS) due per solicitation
Supports research on engineered systems with a seamless integration of cyber and physical components, such as computation, control, networking, learning, autonomy, security, privacy and verification, for a range of application domains. - Robust Intelligence (RI) due per solicitation
Supports computational research in artificial intelligence, machine learning, computer vision, human language technologies and computational neuroscience. - Human-Centered Computing (HCC) due per solicitation
Supports interdisciplinary research in human-computer interaction to design technologies that amplify human capabilities and to study how human, technical and contextual aspects of computing and communication systems shape their benefits, effects and risks. - Networking Technology and Systems (NeTS) due per solicitation
Seeks fundamental scientific understanding of and advances in large-scale, complex, heterogeneous communications networks, including, but not limited to, internet of things (IoT), home, edge, enterprise, data center, cloud, and Internet or Internet-scale networks, and in the wireless areas of cellular, vehicular, mesh, sensor, body area, satellite, and underwater networks. - Software and Hardware Foundations (SHF) due per solicitation
Supports research on the design, evaluation and operation of computer hardware and software.